Manage Your Award. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Study Findings. People over age 40 who have Paget disease of bone a benign condition cancer bone breast by abnormal development of new bone cells are at increased risk of developing osteosarcoma. Large amounts of these enzymes may be present in the blood of people with osteosarcoma or Ewing cancer bone breast.